While Heroes' Paradise is a relatively faithful port, it boasts a handful of changes made to the original build of No More Heroes. Some dialogue was re-recorded; for example, Touchdown's introductory line, "And for you holding the Wii Remote right now" was redubbed, "And for you holding the controller right now." Christel's line, "Too bad there won't be a sequel" was redubbed, "I know. Can't wait to get the sequel," due to the sequel, No More Heroes: Desperate Struggle, which actually did see release. Two of the game's trading cards, Trading Card No. 46 and Trading Card No. 83, were moved from Santa Destroy Junction to the Forest of Bewilderment; the concept art images on most Design Materials trading cards have also been cropped from the bottom, usually cutting out blank canvas but sometimes cutting off the illustrations. The Nintendo 64 resting on Touchdown's motel shelf was altered to a Mega Drive complete with both add-ons, and the layout of the pause menu was completely reworked. In Heroes' Paradise, access to the northern portion of Santa Destroy via bridges has been blocked off. The main bridge has been obstructed by concrete blocks, while the smaller bridge crossing the river has been entirely removed from the map. This means several treasures and dumpster rewards have been relocated to south of these bridges. Because the section of Santa Destroy north of the river has been blocked off in Heroes' Paradise, seven trading cards, 14 Lovikov Balls, eight T-shirts and 12 buried plots of cash have been relocated to other areas of Santa Destroy. You can now open dumpsters/dig spots without getting off Travis' bike. After defeating Dr. Peace, you can examine the spot where Travis left an imprint on after being shot at the start of the fight.
The most significant additions to the game include a new Time Attack mode, online leader boards for the Time Attack, and five bosses from No More Heroes 2: Desperate Struggle. Skelter Helter, Nathan Copeland, Kimmy Howell, Matt Helms, and Alice Twilight appear during dream sequences after certain fights.
Also noteworthy is the fact that in Japan, the Xbox 360 version of Heroes' Paradise is akin to the bloody version of No More Heroes as it was released in North America in 2008, while the region's PlayStation 3 version is devoid of blood in the same manner as the Japanese and European versions of the original product. Because of this, Japan's ratings board, CERO, labeled the Xbox 360 version with a "Z" rating (equivalent to ESRB's "AO" or edgier "M" titles), while the PlayStation 3 version received a "D" rating (equivalent to standard "M" titles). For the PlayStation 3 version of Heroes' Paradise released to English audiences, blood was restored, as it was in Japan when the game was later reissued as No More Heroes: Red Zone.
The following is a rundown of comparisons between the original Wii version of No More Heroes and its subsequent high-definition ports: